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MU 1742

Cat. No. 7979 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective CK1α, CK1δ and CK1ε inhibitor
化学名： 4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MU 1742

MU 1742 is a potent and selective casein kinase 1α (CK1α), CK1δ and CK1ε inhibitor (IC50 values are 6, 7 and 28 nM for CK1δ, CK1α and CK1ε respectively). In vivo, MU 1742 inhibits CK1δ/ε-dependent DVL3 phosphorylation in mouse lung tissue. MU 1742 is orally bioavailable.

许可信息

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1742 probe summary on the SGC website.

技术数据 for MU 1742

分子量 408.46
公式 C22H22F2N6
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 167312208
InChI Key SWOIFXHMBKFCRM-UHFFFAOYSA-N
Smiles FC1=CN=C(C=C1)C2=C(C3=CC=NC4=C3C=CN4)N(CC5(F)CCN(C)CC5)C=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MU 1742

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.85 100
ethanol 40.85 100

制备储备液 for MU 1742

以下数据基于产品分子量 408.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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参考文献 for MU 1742

参考文献是支持产品生物活性的出版物。

Němec et al (2023) Discovery of potent and exquisitely selective inhibitors of kinase CK1 with tunable isoform selectivity. Angew.Chem.Int.Ed.Engl. 62 e202217532 PMID: 36625768

If you know of a relevant reference for MU 1742, please let us know.

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关键词: MU 1742, MU 1742 supplier, MU1742, casein, kinases, inhibitors, inhibits, CK1epsilon, CK1delta, CK1alpha, selective, potent, SGC, in, vivo, orally, bioavailable, CK1α, CK1δ, CK1ε, Casein, Kinase, 1, 7979, Tocris Bioscience

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