Nafamostat mesylate

Name: Nafamostat mesylate
Brand: Tocris Bioscience
SKU: 3081
Rating: 3 (1 reviews)

Cat. No. 3081 1 次引用 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Serine protease inhibitor; inhibits tryptase

化学名： 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nafamostat mesylate

Nafamostat mesylate is a broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC₅₀ = 22.50 μM).

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

化合物库 for Nafamostat mesylate

Nafamostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Nafamostat mesylate

分子量	539.59
公式	C₁₉H₁₇N₅O₂.2CH₄O₃S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	82956-11-4
PubChem ID	54953
InChI Key	SRXKIZXIRHMPFW-UHFFFAOYSA-N
Smiles	CS(=O)(O)=O.NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nafamostat mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	53.96	100
	DMSO	53.96	100

制备储备液 for Nafamostat mesylate

以下数据基于产品分子量 539.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.27 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for Nafamostat mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nafamostat mesylate

参考文献是支持产品生物活性的出版物。

Mori et al (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 92 420 PMID: 12939527

Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 138 959 PMID: 12642398

Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 118 105 PMID: 16815145

Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 30 269 PMID: 32020029

If you know of a relevant reference for Nafamostat mesylate, please let us know.

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1 篇 Nafamostat mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nafamostat mesylate 的部分引用包括：

Scott et al (2018) Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Sci Rep 8 3363 PMID: 29463838

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