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NAI-N3

Cat. No. 7003 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7003 has been discontinued.

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说明： Reagent for RNA icSHAPE experiments in vivo
化学名： [2-(Azidomethyl)-3-pyridinyl]-1H-imidazol-1-ylmethanone
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for NAI-N3

NAI-N3 is a probe for icSHAPE (in vivo click selective 2'-hydroxyl acylation and profiling experiment). Acylates the 2'-OH in ssRNA. Enables RNA structure profiling in vivo and ex vivo for all four bases. NAI-N3 can be used for site-specific RNA acylation using the RAIL (RNA Acylation at Induced Loops) method or in Apta-Seq to discover new aptamers in selected pools.

技术数据 for NAI-N3

分子量 228.22
公式 C10H8N6O
储存 Store at -20°C
CAS Number 1612756-29-2
PubChem ID 131704490
InChI Key QPSQVTFTPHUCEH-UHFFFAOYSA-N
Smiles [N-]=[N+]=NCC1=C(C(N2C=CN=C2)=O)C=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NAI-N3

参考文献是支持产品生物活性的出版物。

Spitale et al (2015) Structural imprints in vivo decode RNA regulatory mechanisms. Nature 519 486 PMID: 25799993

Lee et al (2017) Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA 23 169 PMID: 27879433

Xiao et al (2020) Site-selective RNA functionalization via DNA-induced structure. J.Am.Chem.Soc. 142 16357 PMID: 32865995

Abdelsayed et al (2017) Multiplex aptamer discovery through Apta-Seq and its application to ATP aptamers derived from human-genomic SELEX. ACS Chem.Biol. 12 2149 PMID: 28661647

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关键词: NAI-N3, NAI-N3 supplier, icSHAPE, RNA, reagent, probe, in, vivo, click, selective, 2prime, -hydroxyl, acylation, and, profiling, experiment, Apta-Seq, RAIL, DNA,, Protein, Synthesis, Biochemicals, Molecular, Biology, 7003, Tocris Bioscience

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