NAI

Cat. No. 7004 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable

化学名： 1H-Imidazol-1-yl(2-methyl-3-pyridinyl)methanone

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NAI

NAI is a reagent for RNA SHAPE-MaP experiments in live cells. Acylates the 2'-OH in RNA, labels single stranded or flexible regions more than folded regions (SHAPE methodology). Enables analysis of RNA secondary structures at single nucleotide resolution. Exhibits greater signals with lower background than 1M7 for in vivo measurement of the RNA structurome. Also more stable than 1M7 in water. β-mercaptoethanol terminates reaction. Cell permeable.

技术数据 for NAI

分子量	187.2
公式	C₁₀H₉N₃O
储存	Store at -20°C
CAS Number	1055970-47-2
PubChem ID	66563654
InChI Key	OWQPEDNXDCVXJO-UHFFFAOYSA-N
Smiles	CC1=C(C(N2C=CN=C2)=O)C=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NAI

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	374.4	2000

制备储备液 for NAI

以下数据基于产品分子量 187.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
20 mM	0.27 mL	1.34 mL	2.67 mL
100 mM	0.05 mL	0.27 mL	0.53 mL
200 mM	0.03 mL	0.13 mL	0.27 mL
1000 mM	0.01 mL	0.03 mL	0.05 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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产品说明书 for NAI

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NAI

参考文献是支持产品生物活性的出版物。

Lee et al (2017) Comparison of SHAPE reagents for mapping RNA structures inside living cells. RNA 23 169 PMID: 27879433

Kwok et al (2013) Determination of in vivo RNA structure in low-abundance transcripts. Nat.Commun. 4 2971 PMID: 24336128

Spitale et al (2013) RNA SHAPE analysis in living cells. Nat.Chem.Biol. 9 18 PMID: 23178934

If you know of a relevant reference for NAI, please let us know.

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关键词: NAI, NAI supplier, Reagent, RNA, SHAPE, MaP, chemistry, experiments, 1methyl7nitroisatoic, mapping, secondary, tertiary, structures, cell, permeable, in, vivo, DNA,, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 7004, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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NAI