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Napabucasin

Cat. No. 5522 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： STAT3 inhibitor; also blocks cancer stem cell self-renewal
化学名： 2-Acetylnaphtho[2,3-b]furan-4,9-dione
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Napabucasin

Napabucasin is a STAT3 inhibitor. Blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells. Inhibits PaCa-2 xenograft tumor growth in mice, even after cessation of treatment, and decreases population of CSCs in PaCa-2 tumors from treated mice. Also blocks spleen and liver metastases of colon cancer cells in a mouse model.

化合物库 for Napabucasin

Napabucasin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Napabucasin

分子量 240.21
公式 C14H8O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 83280-65-3
PubChem ID 10331844
InChI Key DPHUWDIXHNQOSY-UHFFFAOYSA-N
Smiles O=C(C1=C2C=C(C(C)=O)O1)C3=CC=CC=C3C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Napabucasin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.8 20

制备储备液 for Napabucasin

以下数据基于产品分子量 240.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 20.82 mL 104.08 mL 208.15 mL
1 mM 4.16 mL 20.82 mL 41.63 mL
2 mM 2.08 mL 10.41 mL 20.82 mL
10 mM 0.42 mL 2.08 mL 4.16 mL

Molarity Calculator

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参考文献 for Napabucasin

参考文献是支持产品生物活性的出版物。

Li et al (2015) Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc.Natl.Acad.Sci.USA. 112 1839 PMID: 25605917

If you know of a relevant reference for Napabucasin, please let us know.

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关键词: Napabucasin, Napabucasin supplier, Stat3, inhibitors, inhibits, cancer, stem, cell, stemness, high, self-renewal, spherogenesis, metastasis, STAT, Stem, Cell, Signaling, Cancer, Cells, 5522, Tocris Bioscience

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Pathways for Napabucasin

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.