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说明： Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
化学名： 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
纯度： ≥97% (HPLC)
生物活性 for NCL 00017509
NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.
技术数据 for NCL 00017509
| 分子量 | 292.3 |
| 公式 | C15H12N6O |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1507367-00-1 |
| PubChem ID | 56944360 |
| InChI Key | CJQGLUJHMXCLQY-UHFFFAOYSA-N |
| Smiles | C#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NCL 00017509
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 29.23 | 100 |
制备储备液 for NCL 00017509
以下数据基于产品分子量 292.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.11 mL | 34.21 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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产品说明书 for NCL 00017509
参考文献 for NCL 00017509
参考文献是支持产品生物活性的出版物。
Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141 PMID: 24213855
Zhang et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat.Commun. 12 4536 PMID: 34315872
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关键词: NCL 00017509, NCL 00017509 supplier, NCL00017509, NIMA, related, kinase, 2, NEK2, inhibitors, inhibits, mitotic, delay, Nek2, Kinase, 5150, Tocris Bioscience
1 篇 NCL 00017509 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NCL 00017509 的部分引用包括：
Zhang et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat Commun. 12 4536 PMID: 34315872
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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