主页 / 细胞生物学 / Cell Metabolism / DNA, RNA and Protein Synthesis / DNA, RNA and Protein Synthesis Inhibitors / Nelarabine

Nelarabine

Cat. No. 6359 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Purine nuceloside analog; inhibits DNA synthesis
别名： GW 506U78
化学名： 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Nelarabine

Nelarabine is a nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.

化合物库 for Nelarabine

Nelarabine is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Nelarabine

分子量 297.27
公式 C11H15N5O5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 121032-29-9
PubChem ID 3011155
InChI Key IXOXBSCIXZEQEQ-UHTZMRCNSA-N
Smiles COC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C=N2)=NC(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nelarabine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.73 100
water 2.97 10 温和加热

制备储备液 for Nelarabine

以下数据基于产品分子量 297.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Nelarabine

参考文献是支持产品生物活性的出版物。

Lambe et al (1995) 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 55 3352 PMID: 7614470

Beesley et al (2007) In vitro cytotoxicity of nelarabine, clofar. and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 137 109 PMID: 17391490

Reilly and Kisor et al (2009) Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2 219 PMID: 20616909

If you know of a relevant reference for Nelarabine, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA, RNA and Protein Synthesis Inhibitors

关键词: Nelarabine, Nelarabine supplier, GW506U78, nucleoside, analogs, analogues, prodrugs, purine, antimetabolites, ara-GTP, chemotherapeutics, GW, 506U78, DNA,, RNA, and, Protein, Synthesis, 6359, Tocris Bioscience

篇 Nelarabine 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Nelarabine 的引用文献。 您是否知道使用了 Tocris Nelarabine 的优秀论文？ 请告知我们.

Nelarabine 的评论

目前没有该产品的评论。 Be the first to review Nelarabine and earn rewards!

Have you used Nelarabine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells