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说明： Syk kinase inhibitor; inhibits Aβ production
化学名： 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
纯度： ≥99% (HPLC)
生物活性 for Nilvadipine
Syk inhibitor. Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro. Enhances clearance of Aβ across the blood brain barrier in vivo. Reduces brain Aβ levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.
技术数据 for Nilvadipine
| 分子量 | 385.37 |
| 公式 | C19H19N3O6 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 75530-68-6 |
| PubChem ID | 4494 |
| InChI Key | FAIIFDPAEUKBEP-UHFFFAOYSA-N |
| Smiles | O=C(OC)C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Nilvadipine
参考文献 for Nilvadipine
参考文献是支持产品生物活性的出版物。
Paris et al (2014) The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J.Biol.Chem. 289 33927 PMID: 25331948
Cho et al (1989) Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J.Med.Chem. 32 2399 PMID: 2552119
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关键词: Nilvadipine, Nilvadipine supplier, syk, inhibitors, inhibits, amyloid, beta, AB, Abeta, spleen, tyrosine, kinases, Alzheimer, disease, APP, precursor, protein, L-type, calcium, channel, blockers, Ca2+, β, Syk, Kinase, Cav1.x, Channels, 5711, Tocris Bioscience
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