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NMS 873

Cat. No. 6180 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective p97 ATPase (VCP) allosteric inhibitor
化学名： 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NMS 873

NMS 873 is a potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.

化合物库 for NMS 873

NMS 873 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NMS 873

分子量 520.67
公式 C27H28N4O3S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1418013-75-8
PubChem ID 71521142
InChI Key UJGTUKMAJVCBIS-UHFFFAOYSA-N
Smiles CC1=C(C2=CC=C(S(C)(=O)=O)C=C2)C=CC(OCC3=NN=C(N3C4=CN=CC=C4)SC5CCCC5)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NMS 873

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.07 100

制备储备液 for NMS 873

以下数据基于产品分子量 520.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.6 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for NMS 873

参考文献是支持产品生物活性的出版物。

Magnaghi et al (2013) Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat.Chem.Biol. 9 548 PMID: 23892893

Anderson et al (2015) Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis. Cancer Cell 28 653 PMID: 26555175

Polucci et al (2013) Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. J.Med.Chem. 56 437 PMID: 23245311

If you know of a relevant reference for NMS 873, please let us know.

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关键词: NMS 873, NMS 873 supplier, NMS873, Potent, selective, valosine, containing, protein, VCP, p97, allosteric, inhibitors, inhibits, unfolded, response, UPR, autophagosome, maturation, antiproliferative, anticancer, Autophagy, Other, ER, stress/UPR, ATPase, Translocation, 6180, Tocris Bioscience

4 篇 NMS 873 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NMS 873 的部分引用包括：

Manu et al (2020) Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function. Cytokine 129 154944 PMID: 32146280

Yong et al (2020) Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Mol Cell 79 824-835.e5 PMID: 32649882

Oscar et al (2021) USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork. Cell Rep 37 109819 PMID: 34644576

Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429

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NMS 873 的评论

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NMS on Dictyostelium mTORC1.
By Judith Schaf on 05/23/2019
分析类型： In Vitro
种属： Other

Used NMS at 30 nM and 300 nM in Dictyostelium, treated for 1 hour or 24 hours. Then mTORC1 activity was monitored using a western blot for p-4E-BP1. No significant change in p-4E-BP1 levels was observed

review image

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