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NQDI 1

Cat. No. 4429 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4429 has been discontinued.

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说明： ASK1 inhibitor
化学名： 2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for NQDI 1

NQDI 1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).

技术数据 for NQDI 1

分子量 319.31
公式 C19H13NO4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 175026-96-7
PubChem ID 5522952
InChI Key UFJGFNHRMPMALC-UHFFFAOYSA-N
Smiles O=C2NC1=CC=CC4=C1C(C3=CC=CC=C3C4=O)=C2C(OCC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NQDI 1

参考文献是支持产品生物活性的出版物。

Bu et al (2001) Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 44 2004 PMID: 11384245

Volynets et al (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 54 2680 PMID: 21449566

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关键词: NQDI 1, NQDI 1 supplier, NQDI1, Apoptosis, signal-regulating, kinase, ASK1, inhibitors, inhibits, MAP3K5, 4429, Tocris Bioscience

1 篇 NQDI 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NQDI 1 的部分引用包括：

Song and Lee (2015) ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition. Psychopharmacology (Berl) 9 198 PMID: 26041997

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