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NSC 109555 ditosylate

Cat. No. 3034 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective Chk2 inhibitor
别名： DDUG
化学名： 2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate)
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NSC 109555 ditosylate

NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

技术数据 for NSC 109555 ditosylate

分子量 752.86
公式 C19H24N10O.2C7H8O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 66748-43-4
PubChem ID 12449850
InChI Key DIQGNVANOSOABS-XMDRLFCYSA-N
Smiles O=C(NC2=CC=C(/C(C)=N/NC(N)=N)C=C2)NC1=CC=C(/C(C)=N/NC(N)=N)C=C1.CC3=CC=C(S(=O)(O)=O)C=C3.CC4=CC=C(S(=O)(O)=O)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NSC 109555 ditosylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.53 10

制备储备液 for NSC 109555 ditosylate

以下数据基于产品分子量 752.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 13.28 mL 66.41 mL 132.83 mL
0.5 mM 2.66 mL 13.28 mL 26.57 mL
1 mM 1.33 mL 6.64 mL 13.28 mL
5 mM 0.27 mL 1.33 mL 2.66 mL

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产品说明书 for NSC 109555 ditosylate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for NSC 109555 ditosylate

参考文献是支持产品生物活性的出版物。

Byczkowski et al (1981) Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 30 2851 PMID: 6895596

Byczkowski et al (1982) Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 42 3592 PMID: 6896674

Jobson et al (2007) Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 72 876 PMID: 17616632

If you know of a relevant reference for NSC 109555 ditosylate, please let us know.

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关键词: NSC 109555 ditosylate, NSC 109555 ditosylate supplier, Selective, Chk2, inhibitors, inhibits, Checkpoint, Kinases, Control, NSC109555, ditosylate, DDUG, 3034, Tocris Bioscience

3 篇 NSC 109555 ditosylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 109555 ditosylate 的部分引用包括：

Luo et al (2011) Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol 85 8046 PMID: 21680529

Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13 408 PMID: 24247150

Duong et al (2013) Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcit. J Cell Mol Med 17 1261 PMID: 23855452

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