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NSC 74859

Cat. No. 4655 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective STAT3 inhibitor
别名： S3I-201
化学名： 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NSC 74859

NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.

化合物库 for NSC 74859

NSC 74859 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NSC 74859

分子量 365.36
公式 C16H15NO7S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 501919-59-1
PubChem ID 252682
InChI Key HWNUSGNZBAISFM-UHFFFAOYSA-N
Smiles CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NSC 74859

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.54 100

制备储备液 for NSC 74859

以下数据基于产品分子量 365.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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参考文献 for NSC 74859

参考文献是支持产品生物活性的出版物。

Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961 PMID: 19137011

Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391 PMID: 17463090

If you know of a relevant reference for NSC 74859, please let us know.

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关键词: NSC 74859, NSC 74859 supplier, NSC74859, STAT3, inhibitors, inhibits, DNA-binding, apoptosis, S3I-201, STAT, 4655, Tocris Bioscience

2 篇 NSC 74859 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 74859 的部分引用包括：

Yuan-Soon et al (2019) The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration. Cancers (Basel) 11 PMID: 31835799

Edmund C et al (2020) Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer. Front Oncol 10 587132 PMID: 33330068

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Pathways for NSC 74859

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.