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Submit ReviewNU 7026
说明： Selective DNA-PK inhibitor
化学名： 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
纯度： ≥98% (HPLC)
生物活性 for NU 7026
NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
技术数据 for NU 7026
| 分子量 | 281.31 |
| 公式 | C17H15NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 154447-35-5 |
| PubChem ID | 9860529 |
| InChI Key | KKTZALUTXUZPSN-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=C3C(C=CC=C3)=C1OC(N4CCOCC4)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NU 7026
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 2.81 | 10 |
制备储备液 for NU 7026
以下数据基于产品分子量 281.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.55 mL | 177.74 mL | 355.48 mL |
| 0.5 mM | 7.11 mL | 35.55 mL | 71.1 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.55 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
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产品说明书 for NU 7026
参考文献 for NU 7026
参考文献是支持产品生物活性的出版物。
Veuger et al (2003) Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I. Cancer Res. 63 6008 PMID: 14522929
Amrein et al (2007) Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J.Pharmacol.Exp.Ther. 321 848 PMID: 17351105
Hollick et al (2003) 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK). Bioorg.Med.Chem.Letts. 13 3083 PMID: 12941339
If you know of a relevant reference for NU 7026, please let us know.
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关键词: NU 7026, NU 7026 supplier, Selective, DNA-dependent, protein, kinases, inhibitors, inhibits, DNA-PK, NU7026, hematopoietic, haematopoietic, stem, cells, HSC, Protein, Kinase, Checkpoint, Control, Kinases, Hematopoietic, Stem, Cells, CRISPR, Reagents, 2828, Tocris Bioscience
14 篇 NU 7026 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NU 7026 的部分引用包括：
Sultana et al (2013) Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res 73 1621 PMID: 23253910
Petruccelli et al (2013) Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis. Mol Cancer Ther 12 1591 PMID: 23536727
Yousefzadeh et al (2014) Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet 10 e1004654 PMID: 25275444
Tang et al (2012) Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. J Neurosci 13 665 PMID: 22334513
Nakahara et al (2015) Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. Chembiochem 89 5040 PMID: 25717108
Jaiswal et al (2017) ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J 36 2161 PMID: 28607002
You et al (2015) Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. Elife 4 PMID: 26437452
Dolman et al (2015) DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS One 10 e0145744 PMID: 26716839
Bohgaki et al (2011) Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet 7 e1001381 PMID: 21552324
Allen et al (2015) DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol 5 260 PMID: 26697402
Rodgers et al (2015) Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst) 27 19 PMID: 25625798
Fard et al (2013) The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle 13 408 PMID: 24247150
Kanai et al (2012) Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells. J Natl Cancer Inst 104 42 PMID: 22173583
Ando et al (2012) PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell 47 681 PMID: 22854598
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NU 7026 的评论
平均评分: 5 (Based on 1 Review.)
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DNAPKi.
By
Isabelle Cristine da Costa on 09/23/2021
分析类型： In Vitro
种属： Human
细胞系/组织： U2OS
I used the DNA-PK inhibitor (NU7026) to treat human osteosarcoma cells (U2OS) and assessed if the inhibition worked by blotting for pDNA-PKcs (S2056). The inhibitor works extremely well!
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.