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Submit ReviewOG 488 BAPTA-1 AM
说明： Cell-permeable, fluorescent Ca2+ indicator
化学名： N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[4-[[[3',6'-bis(acetyloxy)-2',7'-difluoro-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]carbonyl]amino]-2-[2-[2-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]phenoxy]ethoxy]phenyl]glycine (acetyloxy)methyl ester
纯度： ≥90% (HPLC)
生物活性 for OG 488 BAPTA-1 AM
OG 488 BAPTA-1 AM is a cell-permeable, fluorescently labeled Ca2+ indicator (Kd =170 nM). Composed of a green fluorescent probe (OG 488, Cat. No. 6257) conjugated to a cell-permeable Ca2+ chelator (BAPTA AM, Cat. No. 2787). Fluorescent intensity increases approximately 14-fold from resting intensity, upon Ca2+ binding. Displays uniform cellular distribution with minimal subcellular compartmentalization. Excitation/emission λ 494/523 nm.
Optical Data for OG 488 BAPTA-1 AM
| Emission Color | Green |
|---|---|
| λabs | 494 nm |
| λem | 523 nm |
| Extinction Coefficient (ε) | 19000 M-1cm-1 |
| Quantum Yield (φ) | 0.91 |
| Closest Laser line | 488 nm |
| Cell Permeable | Yes |
| Application | Flow Cytometry, Fluorescence Microscopy |
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技术数据 for OG 488 BAPTA-1 AM
| 分子量 | 1258.06 |
| 公式 | C59H53F2N3O26 |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 244167-57-5 |
| PubChem ID | 102028682 |
| InChI Key | NQVWLDWXFNDFLA-UHFFFAOYSA-N |
| Smiles | FC1=CC2=C(C3=CC=C(C(NC4=CC=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(OCCOC5=CC=CC=C5N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=C4)=O)C=C3C([O-])=O)C6=CC(F)=C(OC(C)=O)C=C6[O+]=C2C=C1OC(C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for OG 488 BAPTA-1 AM
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 1.26 | 1 |
制备储备液 for OG 488 BAPTA-1 AM
以下数据基于产品分子量 1258.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.01 mM | 79.49 mL | 397.44 mL | 794.87 mL |
| 0.05 mM | 15.9 mL | 79.49 mL | 158.97 mL |
| 0.1 mM | 7.95 mL | 39.74 mL | 79.49 mL |
| 0.5 mM | 1.59 mL | 7.95 mL | 15.9 mL |
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产品说明书 for OG 488 BAPTA-1 AM
参考文献 for OG 488 BAPTA-1 AM
参考文献是支持产品生物活性的出版物。
Thomas et al (2000) A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals Cell Calcium 28 213 PMID: 11032777
If you know of a relevant reference for OG 488 BAPTA-1 AM, please let us know.
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关键词: OG 488 BAPTA-1 AM, OG 488 BAPTA-1 AM supplier, OG488, BAPTA-1AM, fluorescent, calcium, indicator, chelator, cell, permeable, Ion, Indicators, General, Calcium, Signaling, Agents, Fluorescent, 6256, Tocris Bioscience
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