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说明： Induces abnormal nuclear aggregation of PKCι; proapoptotic
化学名： 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
纯度： ≥98% (HPLC)
生物活性 for Oncrasin 1
Oncrasin 1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.
技术数据 for Oncrasin 1
| 分子量 | 269.73 |
| 公式 | C16H12ClNO |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 75629-57-1 |
| PubChem ID | 872445 |
| InChI Key | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
| Smiles | O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Oncrasin 1
参考文献 for Oncrasin 1
参考文献是支持产品生物活性的出版物。
Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441 PMID: 19208825
Guo et al (2007) Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res. 68 7403
关键词: Oncrasin 1, Oncrasin 1 supplier, Induces, abnormal, nuclear, aggregation, PKCiota, proapoptotic, Protein, Kinases, C, Apoptosis, Inducers, Oncrasin1, Kinase, 3427, Tocris Bioscience
1 篇 Oncrasin 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Oncrasin 1 的部分引用包括：
Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261
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