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Submit ReviewOXA 06 dihydrochloride
说明： Potent ROCK inhibitor
化学名： 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for OXA 06 dihydrochloride
OXA 06 dihydrochloride is a potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.
技术数据 for OXA 06 dihydrochloride
| 分子量 | 404.31 |
| 公式 | C21H18FN3.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1825455-91-1 |
| PubChem ID | 91691120 |
| InChI Key | ZRBCUSMZOWMVJS-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC=C1CNCC(C=C4)=CC=C4C2=C3C(NC=C3)=NC=C2.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for OXA 06 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.43 | 100 |
制备储备液 for OXA 06 dihydrochloride
以下数据基于产品分子量 404.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.37 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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产品说明书 for OXA 06 dihydrochloride
参考文献 for OXA 06 dihydrochloride
参考文献是支持产品生物活性的出版物。
Vigil et al (2012) ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 72 5338 PMID: 22942252
If you know of a relevant reference for OXA 06 dihydrochloride, please let us know.
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关键词: OXA 06 dihydrochloride, OXA 06 dihydrochloride supplier, OXA06, dihydrochloride, rho, kinases, ROCK, potent, inhibitors, inhibits, 944955_32_2, Rho-kinases, 5182, Tocris Bioscience
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