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Submit ReviewOXSI 2 is a potent Syk kinase inhibitor (IC50 = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.
分子量 | 353.39 |
公式 | C18H15N3O3S |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 622387-85-3 |
PubChem ID | 24906266 |
InChI Key | MLKHXLFEYOOYEY-UHFFFAOYSA-N |
Smiles | CN1C=C(/C=C2C(NC3=CC=C(C=C\23)S(N)(=O)=O)=O)C4=CC=CC=C14 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Lai et al (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg.Med.Chem.Lett. 13 3111 PMID: 12941345
Yaron et al (2016) The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem.Biophys.Res.Commun. 472 545 PMID: 26970308
关键词: OXSI 2, OXSI 2 supplier, OXSI2, Inhibitors, inhibits, Syk, kinase, NLRPL3, inflammasome, caspase-1, IL-1beta, IL-1b, IL-1β, mitochondria, ROS, pyroptosis, inflammation, Kinase, Inflammasomes, 6012, Tocris Bioscience
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