OXSI 2

Discontinued Product

6012 has been discontinued.

View all Syk Kinase products.
说明: Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes
化学名: 2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
纯度: ≥98% (HPLC)
说明书
引用文献
评论

生物活性 for OXSI 2

OXSI 2 is a potent Syk kinase inhibitor (IC50 = 14 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin (Cat.No. 4312). Also inhibits the activation of caspase-1, IL-1β processing and release, mitochondrial ROS generation and pyroptic cell death in mouse macrophage cells.

技术数据 for OXSI 2

分子量 353.39
公式 C18H15N3O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 622387-85-3
PubChem ID 24906266
InChI Key MLKHXLFEYOOYEY-UHFFFAOYSA-N
Smiles CN1C=C(/C=C2C(NC3=CC=C(C=C\23)S(N)(=O)=O)=O)C4=CC=CC=C14

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for OXSI 2

参考文献是支持产品生物活性的出版物。

Lai et al (2003) Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorg.Med.Chem.Lett. 13 3111 PMID: 12941345

Yaron et al (2016) The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem.Biophys.Res.Commun. 472 545 PMID: 26970308

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关键词: OXSI 2, OXSI 2 supplier, OXSI2, Inhibitors, inhibits, Syk, kinase, NLRPL3, inflammasome, caspase-1, IL-1beta, IL-1b, IL-1β, mitochondria, ROS, pyroptosis, inflammation, Kinase, Inflammasomes, 6012, Tocris Bioscience

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