P 22077

Cat. No. 4485 5 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： USP7 inhibitor

化学名： 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone

纯度： ≥99% (HPLC)

说明书

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for P 22077

P 22077 is an inhibitor of ubiquitin-specific protease (USP) 7 (EC₅₀ = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

化合物库 for P 22077

P 22077 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for P 22077

分子量	315.32
公式	C₁₂H₇F₂NO₃S₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1247819-59-5
PubChem ID	46931953
InChI Key	RMAMGGNACJHXHO-UHFFFAOYSA-N
Smiles	CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for P 22077

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.53	100

制备储备液 for P 22077

以下数据基于产品分子量 315.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL
10 mM	0.32 mL	1.59 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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产品说明书 for P 22077

分析证书/产品说明书

化学品安全技术说明书

参考文献 for P 22077

参考文献是支持产品生物活性的出版物。

Loch et al (2011) Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiers. Mol.Cell.Proteomics 10 M100.002402 PMID: 20956615

Tian et al (2011) Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev.Technol. 9 165 PMID: 21133675

Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401 PMID: 22118674

Dar et al (2013) Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway. Mol.Cell Biol. 33 3309 PMID: 23775119

If you know of a relevant reference for P 22077, please let us know.

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关键词: P 22077, P 22077 supplier, P22077, inhibitors, inhibits, ubiquitin-specific, proteases, USP7, DUB, HDM2, claspin, ubiquitin, deubiquitination, anticancer, hausp, Deubiquitinating, Enzymes, 4485, Tocris Bioscience

5 篇 P 22077 的引用文献

引用文献是使用了 Tocris 产品的出版物。 P 22077 的部分引用包括：

Lecona et al (2015) USP7 cooperates with SCML2 to regulate the activity of PRC1. Pharmacol Res Perspect 35 1157 PMID: 25605328

Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734

Oscar et al (2021) USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork. Cell Rep 37 109819 PMID: 34644576

Ji et al (2019) USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin. Nat Commun 10 4184 PMID: 31519875

Lecona et al (2016) USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol 23 270 PMID: 26950370

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P 22077 的评论

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P22077 was seen to induce tumor cell death.

By Anonymous on 12/14/2019

种属： Human

P22077 was seen to induce (tumor) cell death with EC50 values in the low micromolar range. P22077 inhibition exhibited changes in ubiquitylated protein levels that are distinct from the broad specificity inhibitor.

USP7 inhibitors 2 (P22077).

By Anonymous on 12/10/2019

分析类型： In Vitro