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Submit ReviewPF 06650833
说明： Potent and selective IRAK4 inhibitor
化学名： 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for PF 06650833
PF 06650833 is a potent and selective IRAK4 inhibitor (IC50 = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 06650833
| 分子量 | 361.37 |
| 公式 | C18H20FN3O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1817626-54-2 |
| PubChem ID | 118414016 |
| InChI Key | JKDGKIBAOAFRPJ-ZBINZKHDSA-N |
| Smiles | CC[C@H]1[C@H](NC([C@H]1F)=O)COC2=NC=CC3=C2C=C(C(C(N)=O)=C3)OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 06650833
参考文献 for PF 06650833
参考文献是支持产品生物活性的出版物。
Lee et al (2017) Discovery of clinical candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a potent, selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) J.Med.Chem. 60 6621 PMID: 28498658
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关键词: PF 06650833, PF 06650833 supplier, PF06650833, IRAK4, Interleukin-1, receptor-associated, kinases, potent, selective, orally, bioavailable, IRAK, Cytokines, 6373, Tocris Bioscience
2 篇 PF 06650833 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PF 06650833 的部分引用包括：
Clare E et al (2022) The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep 40 111225 PMID: 35977521
Jianfeng et al (2022) Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats. Brain Behav Immun 101 37-48 PMID: 34958862
PF 06650833 的评论
平均评分: 5 (Based on 1 Review.)
Have you used PF 06650833?
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Works well for kinase assay.
By
Scott Scarneo on 02/06/2019
分析类型： In Vitro
种属： Human
Easy to use and store. I used this assay for a kinase assay against TAK1 in vitro of purified TAK-TAB1.
