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Submit ReviewPI 3065
说明： Potent and selective PI 3-kinase p110δ inhibitor
化学名： 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
纯度： ≥98% (HPLC)
生物活性 for PI 3065
PI 3065 is a potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.
技术数据 for PI 3065
| 分子量 | 506.64 |
| 公式 | C27H31FN6OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 955977-50-1 |
| PubChem ID | 24937012 |
| InChI Key | YDNOHCOYQVZOMC-UHFFFAOYSA-N |
| Smiles | FC1=CC=C2NC=CC2=C1C3=NC(N4CCOCC4)=C5SC(CN6CCN(CC6)CC7CC7)=CC5=N3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PI 3065
参考文献 for PI 3065
参考文献是支持产品生物活性的出版物。
Ali et al (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510 407 PMID: 24919154
Porta et al (2014) Targeting PI3K/Akt/mTOR signaling in cancer. Front.Oncol. 4 64 PMID: 24782981
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关键词: PI 3065, PI 3065 supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinases, inhibitors, inhibits, potent, selective, p110d, delta, δ, 3-Kinase, 5919, Tocris Bioscience
1 篇 PI 3065 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PI 3065 的部分引用包括：
Cornelis F et al (2017) Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity 47 1067-1082.e12 PMID: 29246441
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