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Piperlongumine

Cat. No. 4396 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4396 has been discontinued.

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说明： Induces apoptosis; increases p53 and ROS levels in cancer cells
化学名： 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Piperlongumine

Piperlongumine is an induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.

技术数据 for Piperlongumine

分子量 317.34
公式 C17H19NO5
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 20069-09-4
PubChem ID 637858
InChI Key VABYUUZNAVQNPG-BQYQJAHWSA-N
Smiles O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Piperlongumine

参考文献是支持产品生物活性的出版物。

Raj et al (2011) Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475 231 PMID: 21753854

Golovine et al (2012) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate [Epub ahead of print] PMID: 22592999

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1 篇 Piperlongumine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Piperlongumine 的部分引用包括：

Farrand et al (2013) An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells. PLoS One 8 e74008 PMID: 24040144

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Piperlongumine

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.