PKC ζ pseudosubstrate

Name: PKC ζ pseudosubstrate
Brand: Tocris Bioscience
SKU: 1791

Cat. No. 1791 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1791 has been discontinued.

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说明： PKC ζ inhibitor peptide (attached to cell-permeable vector)

别名： Protein kinase C zeta pseudosubstrate

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for PKC ζ pseudosubstrate

PKC ζ pseudosubstrate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.

技术数据 for PKC ζ pseudosubstrate

分子量	4673.59
公式	C₂₀₈H₃₃₆N₇₄O₄₄S₃
序列	CRQIKIWFQNRRMKWKK CSIYRRGARRWRKLYRAN* (Modifications: Disulfide bridge between 1 -1*)
储存	Store at -20°C
PubChem ID	90488711
InChI Key	BQLVLLVGFUIFFK-OXSGATHOSA-N
Smiles	[H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PKC ζ pseudosubstrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PKC ζ pseudosubstrate

参考文献是支持产品生物活性的出版物。

Laudanna et al (1998) Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 273 30306 PMID: 9804792

Lim et al (2008) A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity. Life Sci. 82 733 PMID: 18289606

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470

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关键词: PKC z pseudosubstrate, PKC z pseudosubstrate supplier, PKC, zeta, inhibitors, inhibits, Protein, Kinases, C, pseudosubstrate, PKCz, ProteinkinaseC, kinase, Kinase, 1791, Tocris Bioscience

2 篇 PKC ζ pseudosubstrate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PKC ζ pseudosubstrate 的部分引用包括：

Mu et al (2011) TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun 2 330 PMID: 21629263

Mattson et al (2019) Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice. J Biol Chem PMID: 31189651