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Submit ReviewPKI 14-22 amide, myristoylated
说明： Cell-permeable protein kinase A inhibitor
别名： Protein kinase inhibitor-(14-22)-amide,myristoylated
纯度： ≥95% (HPLC)
生物活性 for PKI 14-22 amide, myristoylated
PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).
技术数据 for PKI 14-22 amide, myristoylated
| 分子量 | 1209.5 |
| 公式 | C53H100N20O12 |
| 序列 |
GRTGRRNAI (Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 201422-03-9 |
| PubChem ID | 71312213 |
| InChI Key | GQPQKQWUUHDDIS-JDLJUXOTSA-N |
| Smiles | [H]N(CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)C(=O)CCCCCCCCCCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PKI 14-22 amide, myristoylated
| 溶解性 | Soluble to 1 mg/ml in DMSO |
产品说明书 for PKI 14-22 amide, myristoylated
参考文献 for PKI 14-22 amide, myristoylated
参考文献是支持产品生物活性的出版物。
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802 PMID: 2722799
Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747 PMID: 10829013
Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197 PMID: 12947318
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关键词: PKI 14-22 amide, myristoylated, PKI 14-22 amide, myristoylated supplier, Cell-permeable, protein, kinases, A, inhibitors, inhibits, Cell, permeable, PKA, PKI14-22, amide, myristoylated, Protein, kinase, inhibitor-(14-22)-amide,, Kinase, 2546, Tocris Bioscience
16 篇 PKI 14-22 amide, myristoylated 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PKI 14-22 amide, myristoylated 的部分引用包括：
Stival et al (2018) Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J Biol Chem 293 9435 PMID: 29700114
Muñoz-Llancao et al (2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Exp Med 35 11315 PMID: 26269639
Watson et al (2015) Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Biol Chem 212 1021 PMID: 26101266
Singh et al (2015) The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem NULL PMID: 26451044
Tseng et al (2010) PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. Autophagy 285 29925 PMID: 20663885
Okumura et al (2014) Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase. PLoS One 9 e100559 PMID: 24945349
Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369 PMID: 25065880
Hamnett et al (2019) Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Nat Commun 10 542 PMID: 30710088
Hashimotodani et al (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron 95 928 PMID: 28817805
Maddugoda et al (2011) cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host Microbe 10 464 PMID: 22100162
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
Jantarajit et al (2017) CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels. Am J Physiol Cell Physiol 313 C118 PMID: 28490422
Jakobsen et al (2019) Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function. J Neurosci Res 97 1018 PMID: 31172581
Al-Amily et al (2019) The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Pflugers Arch 471 633 PMID: 30767071
Caiati et al (2013) PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci 33 2973 PMID: 23407955
Liu et al (2008) Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci 49 772 PMID: 18235027
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Cyclic AMP Pathway-related studies.
By
MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human
PKI 14-22 amide, myristoylated was used in studies exploring the role of PKA in mediating drug-induced activation of the cyclic AMP pathway.