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Submit ReviewPKI (5-24)
说明： High affinity PKA inhibitor
纯度： ≥95% (HPLC)
生物活性 for PKI (5-24)
PKI (5-24) is a high affinity PKA inhibitor (Ki = 2.3 nM).
技术数据 for PKI (5-24)
| 分子量 | 2222.4 |
| 公式 | C94H148N32O31 |
| 序列 | TTYADFIASGRTGRRNAIHD |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 99534-03-9 |
| PubChem ID | 102397230 |
| InChI Key | AXOXZJJMUVSZQY-LGGJAOENSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PKI (5-24)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for PKI (5-24)
参考文献 for PKI (5-24)
参考文献是支持产品生物活性的出版物。
Cheng et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 261 989 PMID: 3511044
Narayana et al (1997) Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 36 4438 PMID: 9109651
If you know of a relevant reference for PKI (5-24), please let us know.
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关键词: PKI (5-24), PKI (5-24) supplier, High, affinity, PKA, inhibitor, Protein, Kinase, A, 6221, Tocris Bioscience
3 篇 PKI (5-24) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PKI (5-24) 的部分引用包括：
Ruihua et al (2020) Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway. Int J Ophthalmol 13 552-559 PMID: 32399404
Zhou et al (2013) Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats. Learn Mem 20 274 PMID: 23596314
Fuqin et al (2022) HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum. J Physiol 600 4917-4938 PMID: 36181477
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