主页 / Product Type / Reagents / Viral Transduction Enhancers / Protamine sulfate

Protamine sulfate

Cat. No. 8822 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Transduction efficiency enhancer, also apelin receptor antagonist
纯度： ≥90% (HPLC)
说明书
引用文献
评论
实验方案 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Protamine sulfate

Protamine sulfate is a cationic peptide that enhances viral vector transduction efficiency in gene therapy applications. By neutralizing charge repulsion between viral particles and the cell surface, Protamine sulfate promotes vector attachment and uptake, leading to increased transduction efficiency. It is commonly used in combination with Polybrene (Cat. No. 7711) to enhance the delivery of adeno-associated virus (AAV) and lentiviral vectors. Protamine sulfate is widely applied in gene delivery workflows, including stem cell engineering and gene-modified cell therapy development. It is also an antagonist of apelin receptor.

For more information on how to prepare Protamine sulfate for transfection enhancement, please see our protocol.

For more information on how to prepare Protamine sulfate for enhanced-viral-transduction of mammalian cells, please see our protocol.

Protamine sulfate is supplied as a lyophilized solid in a convenient, ready-to-reconstitute vial size. A stock solution can be prepared by adding 1 mL of sterile ultra-pure water directly to the vial (final stock concentration: 10 mg/mL).

技术数据 for Protamine sulfate

储存 Store at +4°C
纯度 ≥90% (HPLC)
CAS Number 53597-25-4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Protamine sulfate

溶解性 Soluble to 10 mg/ml in water with gentle warming

产品说明书 for Protamine sulfate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Protamine sulfate

参考文献是支持产品生物活性的出版物。

Le Gonidec (2017) Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin. FASEB J 31 2507 PMID: 28242772

Ellison et al (2024) Design and validation of a GMP stem cell manufacturing protocol for MPSII hematopoietic stem cell gene therapy. Mol.Ther.Methods Clin.Dev. 32 101271 PMID: 38946936

If you know of a relevant reference for Protamine sulfate, please let us know.

按标靶查看相关产品

关键词: Protamine sulfate, Protamine sulfate supplier, transduction, transfection, retrovirus, enhancers, gene, delivery, enhances, viral, apelin, receptors, antagonists, antagonism, Viral, Transduction, Enhancers, Apelin, Receptors, 8822, Tocris Bioscience

篇 Protamine sulfate 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Protamine sulfate 的引用文献。 您是否知道使用了 Tocris Protamine sulfate 的优秀论文？ 请告知我们.

Protamine sulfate 的评论

目前没有该产品的评论。 Be the first to review Protamine sulfate and earn rewards!

Have you used Protamine sulfate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Protamine sulfate 实验方案

以下实验方案包含使用 Protamine sulfate（目录编号 8822）的更多信息。

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products