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PSI

Cat. No. 4045 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4045 has been discontinued.

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说明： Proteasome inhibitor. Also prevents activation of NF-κB
化学名： N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butyl ester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for PSI

Proteasome inhibitor; inhibits chymotrypsin-like activity of the proteasome. Causes dopaminergic cell death in vitro. Prevents activation of NF-κB in response to TNF-α and okadaic acid (Cat. No. 1136) by inhibiting IκB-α degradation. Also inhibits NO production by LPS-activated macrophages.

技术数据 for PSI

分子量 618.77
公式 C32H50N4O8
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 158442-41-2
PubChem ID 9960660
InChI Key TYFTWYMXUWCOOB-YICLCXKGSA-N
Smiles [H]C([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCC(OC(C)(C)C)=O)NC([C@H]([C@@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PSI

参考文献是支持产品生物活性的出版物。

Traenckner et al (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13 5433 PMID: 7957109

Bukhatwa et al (2009) An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. J.Neurochem. 109 52 PMID: 19187437

Griscavage et al (1996) Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 93 3308

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关键词: PSI, PSI supplier, proteasome, inhibitors, inhibits, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, NF-kB, activation, Proteasome, NF-kB/IkB, 4045, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia