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PT 1

Cat. No. 4039 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4039 has been discontinued.

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说明： AMPK activator
化学名： 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for PT 1

PT 1 is an aMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.

技术数据 for PT 1

分子量 497.91
公式 C23H16ClN3O6S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 331002-70-1
PubChem ID 5753734
InChI Key RTHRCOIONCZINZ-JMIUGGIZSA-N
Smiles ClC1=C(C(O)=O)C=C(/N=C3/NC(/C(S3)=C/C2=CC=C(C4=C([N+]([O-])=O)C=C(C)C(C)=C4)O2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PT 1

参考文献是支持产品生物活性的出版物。

Zorn and Wells (2010) Turning enzymes ON with small molecules. Nat.Chem.Biol. 6 179 PMID: 20154666

Pang et al (2007) Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J.Biol.Chem. 283 16051

Jensen et al (2015) PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. Biochem.J. 467 461 PMID: 25695398

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关键词: PT 1, PT 1 supplier, AMPK, amp-activated, protein, kinase, activators, PT1, Enzyme, Substrates, /, Activators, 4039, Tocris Bioscience

2 篇 PT 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PT 1 的部分引用包括：

Huang et al (2016) The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy. J Cardiovasc Pharmacol Ther 21 70 PMID: 25868658

Asiedu et al (2017) The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development. PLoS One 12 e0169882 PMID: 28118359

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Pathways for PT 1

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.