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RAF 265

Cat. No. 6015 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6015 has been discontinued.

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说明： Raf kinase and VEGFR-2 inhibitor
别名： CHIR 265
化学名： 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for RAF 265

RAF 265 is a Raf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable.

技术数据 for RAF 265

分子量 518.41
公式 C24H16F6N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 927880-90-8
PubChem ID 11656518
InChI Key YABJJWZLRMPFSI-UHFFFAOYSA-N
Smiles CN1C(NC2=CC=C(C=C2)C(F)(F)F)=NC3=CC(OC4=CC=NC(C5=NC=C(C(F)(F)F)N5)=C4)=CC=C13

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for RAF 265

参考文献是支持产品生物活性的出版物。

Chen et al (2011) Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res. 71 4280 PMID: 21527556

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关键词: RAF 265, RAF 265 supplier, RAF265, Raf, kinases, inhibitors, inhibits, B-Raf, c-Raf, VEGFR2, vascular, endothelial, growth, factor, cytotoxic, MAPK, CHIR, 265, Kinase, VEGFR, 6015, Tocris Bioscience

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