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Submit ReviewRCGD 423
说明： gp130 modulator; activates JAK/STAT signaling
化学名： N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
纯度： ≥98% (HPLC)
生物活性 for RCGD 423
RCGD 423 is a gp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.
化合物库 for RCGD 423
RCGD 423 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for RCGD 423
| 分子量 | 331.23 |
| 公式 | C15H11BrN2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 108237-91-8 |
| PubChem ID | 4456143 |
| InChI Key | OUFYYVAASPLOAA-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RCGD 423
参考文献 for RCGD 423
参考文献是支持产品生物活性的出版物。
Flores et al (2017) Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat.Cell Biol. 19 1017 PMID: 28812580
Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS.Chem.Neurosci. 9 462 PMID: 29161500
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.