Ro 32-0432 hydrochloride

Cat. No. 1587 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, orally active PKC inhibitor

化学名： 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride

纯度： ≥99% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ro 32-0432 hydrochloride

Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca²⁺ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

技术数据 for Ro 32-0432 hydrochloride

分子量	489.01
公式	C₂₈H₂₈N₄O₂.HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	1781828-85-0
PubChem ID	70346044
InChI Key	HSPRASOZRZDELU-LMOVPXPDSA-N
Smiles	O=C(N1)C(C2=C6N(CC[C@H](CN(C)C)C6)C3=CC=CC=C23)=C(C(C5=C4C=CC=C5)=CN4C)C1=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ro 32-0432 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	4.89	10 温和加热

制备储备液 for Ro 32-0432 hydrochloride

以下数据基于产品分子量 489.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	20.45 mL	102.25 mL	204.49 mL
0.5 mM	4.09 mL	20.45 mL	40.9 mL
1 mM	2.04 mL	10.22 mL	20.45 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

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产品说明书 for Ro 32-0432 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ro 32-0432 hydrochloride

参考文献是支持产品生物活性的出版物。

Wilkinson et al (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 294 335 PMID: 8373348

Birchall et al (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 268 922 PMID: 8114006

If you know of a relevant reference for Ro 32-0432 hydrochloride, please let us know.

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关键词: Ro 32-0432 hydrochloride, Ro 32-0432 hydrochloride supplier, Potent, orally, active, PKC, inhibitors, inhibits, Protein, Kinases, C, Ro32-0432, hydrochloride, Kinase, 1587, Tocris Bioscience

2 篇 Ro 32-0432 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ro 32-0432 hydrochloride 的部分引用包括：

Robert et al (2009) Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 4 e7889 PMID: 19924252

Signore et al (2014) Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis 5 e1223 PMID: 24810059

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