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Ro 90-7501

Cat. No. 2408 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of Aβ42 fibril formation
化学名： 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ro 90-7501

Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).

化合物库 for Ro 90-7501

Ro 90-7501 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ro 90-7501

分子量 340.39
公式 C20H16N6
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 293762-45-5
PubChem ID 824226
InChI Key PAGZCEHLFCJSPV-UHFFFAOYSA-N
Smiles NC1=CC=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(N)C=C2N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ro 90-7501

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 3.4 10
DMSO 34.04 100

制备储备液 for Ro 90-7501

以下数据基于产品分子量 340.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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产品说明书 for Ro 90-7501

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Ro 90-7501

参考文献是支持产品生物活性的出版物。

Bohrmann et al (2000) Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 130 232 PMID: 10940228

If you know of a relevant reference for Ro 90-7501, please let us know.

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关键词: Ro 90-7501, Ro 90-7501 supplier, inhibitors, inhibits, Aβ4, β42, beta42, fibril, formation, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, beta, Peptides, Ro90-7501, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, 2408, Tocris Bioscience

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