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说明： Reported PKCδ inhibitor
化学名： 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
纯度： ≥95% (HPLC)
生物活性 for Rottlerin
Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
技术数据 for Rottlerin
| 分子量 | 516.55 |
| 公式 | C30H28O8 |
| 储存 | Store at +4°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 82-08-6 |
| PubChem ID | 5281847 |
| InChI Key | DEZFNHCVIZBHBI-ZHACJKMWSA-N |
| Smiles | CC(=O)C1=C(O)C(CC2=C(O)C(C(=O)\C=C\C3=CC=CC=C3)=C3OC(C)(C)C=CC3=C2O)=C(O)C(C)=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Rottlerin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.33 | 20 |
制备储备液 for Rottlerin
以下数据基于产品分子量 516.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.68 mL | 48.4 mL | 96.8 mL |
| 1 mM | 1.94 mL | 9.68 mL | 19.36 mL |
| 2 mM | 0.97 mL | 4.84 mL | 9.68 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
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产品说明书 for Rottlerin
参考文献 for Rottlerin
参考文献是支持产品生物活性的出版物。
Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95 PMID: 10998351
Gschwendt et al (1994) Rottlerin, a novel protein kinase inhibitor. Biochem.Biophys.Res.Commun. 199 93 PMID: 8123051
Zhang et al (2007) Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 322 913 PMID: 17565007
Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124 PMID: 19771169
If you know of a relevant reference for Rottlerin, please let us know.
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关键词: Rottlerin, Rottlerin supplier, Reported, PKCdelta, inhibitors, inhibits, Protein, Kinases, C, Kinase, Autophagy, 1610, Tocris Bioscience
6 篇 Rottlerin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Rottlerin 的部分引用包括：
Pietras et al (2016) Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat Cell Biol 18 607 PMID: 27111842
Barbaric et al (2011) High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. J Biomol Screen 16 603 PMID: 21593487
Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409
Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Bladder (San Franc) 8 e66404 PMID: 23799098
Shu et al (2014) Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS One 9 e95259 PMID: 24748172
Goldklang et al (2013) Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. FASEB J 27 4975 PMID: 23995289
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