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Rp-8-Br-PET-cGMPS

Cat. No. 3028 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Protein kinase G inhibitor
化学名： 2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Rp-8-Br-PET-cGMPS

Rp-8-Br-PET-cGMPS is a competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.

This product is sold in units of 560μg, equivalent to 1μmol.

技术数据 for Rp-8-Br-PET-cGMPS

分子量 562.27
公式 C18H14BrN5NaO6PS
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 185246-32-6
PubChem ID 23695925
InChI Key PNUXBFRWMZKKAJ-IPZAVTHYSA-M
Smiles [H][C@@]([C@@](O[C@@H](N3C(Br)=NC5=C3NC4=NC(C6=CC=CC=C6)=CN4C5=O)[C@@H]2O)([H])CO1)2O[P@@]1(S[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rp-8-Br-PET-cGMPS

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 11.25 20
DMSO 22.49 40

制备储备液 for Rp-8-Br-PET-cGMPS

以下数据基于产品分子量 562.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.4 mM 4.45 mL 22.23 mL 44.46 mL
2 mM 0.89 mL 4.45 mL 8.89 mL
4 mM 0.44 mL 2.22 mL 4.45 mL
20 mM 0.09 mL 0.44 mL 0.89 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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产品说明书 for Rp-8-Br-PET-cGMPS

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Rp-8-Br-PET-cGMPS

参考文献是支持产品生物活性的出版物。

Wei et al (1996) Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35 16815 PMID: 8988020

Qi et al (2007) Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 152 1060 PMID: 17891157

Valtcheva et al (2008) The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 284 556 PMID: 19008225

If you know of a relevant reference for Rp-8-Br-PET-cGMPS, please let us know.

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关键词: Rp-8-Br-PET-cGMPS, Rp-8-Br-PET-cGMPS supplier, Protein, kinase, G, inhibitors, inhibits, PKG, Kinases, cGMP-dependent, Kinase, 3028, Tocris Bioscience

2 篇 Rp-8-Br-PET-cGMPS 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rp-8-Br-PET-cGMPS 的部分引用包括：

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407

Lin et al (2008) Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Cell 37 770 PMID: 18289871

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PKG inhibitor in vitro.
By Anonymous on 08/11/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Neuron

Used in cultured neurons at 10 uM

Excellent PKG inhibitor

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