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Rp-8-pCPT-cGMPS sodium

Cat. No. 5524 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： PKG inhibitor
化学名： 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Rp-8-pCPT-cGMPS sodium

Rp-8-pCPT-cGMPS sodium is a PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.

技术数据 for Rp-8-pCPT-cGMPS sodium

分子量 525.86
公式 C16H14ClN5NaO6PS2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 208445-07-2
PubChem ID 91826097
InChI Key JERAACMSJYSCBY-OZOPYAHTSA-M
Smiles O=C1N=C(N)NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](CO[P@](O5)(S[Na])=O)([H])[C@]5([H])[C@H]3O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Rp-8-pCPT-cGMPS sodium

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Rp-8-pCPT-cGMPS sodium

参考文献是支持产品生物活性的出版物。

Kim et al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122 PMID: 25713349

Poppe et al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277 PMID: 18376388

Gamm et al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380 PMID: 7593002

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关键词: Rp-8-pCPT-cGMPS sodium, Rp-8-pCPT-cGMPS sodium supplier, PKG, cGMP-dependent, kinases, PKGIbeta, PKGIb, PKGIμ, PKGIalpha, PKGIa, PKGIα, PKGII, LTP, potentiation, long, term, Protein, Kinase, G, 5524, Tocris Bioscience

1 篇 Rp-8-pCPT-cGMPS sodium 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rp-8-pCPT-cGMPS sodium 的部分引用包括：

Govindapillai et al (2018) Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system. Sci Rep 8 6939 PMID: 29720615

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