Sacubitril calcium

Cat. No. 5772 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

别名： AHU 377

化学名： Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sacubitril calcium

Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

化合物库 for Sacubitril calcium

Sacubitril calcium is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Sacubitril calcium

分子量	430.52
公式	C₂₄H₂₈NO₅.½Ca
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1369773-39-6
PubChem ID	91827885
InChI Key	DDLCKLBRBPYKQS-OXXXZDCLSA-L
Smiles	[Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sacubitril calcium

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	43.05	100
	ethanol	8.61	20

制备储备液 for Sacubitril calcium

以下数据基于产品分子量 430.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.61 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for Sacubitril calcium

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sacubitril calcium

参考文献是支持产品生物活性的出版物。

Ksander et al (1995) Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 38 1689 PMID: 7752193

If you know of a relevant reference for Sacubitril calcium, please let us know.

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