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Submit ReviewSaxagliptin hydrochloride
说明： High affinity DPP-IV inhibitor; active in vivo
别名： BMS 477118
化学名： (1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Saxagliptin hydrochloride
Saxagliptin hydrochloride is a high affinity DPP-IV inhibitor (Ki = 0.6 nM). Inhibits plasma DPP-IV (87%). Elicits enhanced glucose clearance in Zuckerfa/fa rats.
化合物库 for Saxagliptin hydrochloride
Saxagliptin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Saxagliptin hydrochloride
| 分子量 | 351.87 |
| 公式 | C18H25N3O2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 709031-78-7 |
| PubChem ID | 56841574 |
| InChI Key | TUAZNHHHYVBVBR-RIKNOMPASA-N |
| Smiles | N[C@@H](C12CC3CC(C2)CC(C3)(C1)O)C(N4[C@H]5C[C@H]5C[C@H]4C#N)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Saxagliptin hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 35.19 | 100 | |
| DMSO | 35.19 | 100 |
制备储备液 for Saxagliptin hydrochloride
以下数据基于产品分子量 351.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.21 mL | 28.42 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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产品说明书 for Saxagliptin hydrochloride
参考文献 for Saxagliptin hydrochloride
参考文献是支持产品生物活性的出版物。
Augeri et al (2005) Discovery and preclinical profile of saxagl. (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 48 5025 PMID: 16033281
If you know of a relevant reference for Saxagliptin hydrochloride, please let us know.
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关键词: Saxagliptin hydrochloride, Saxagliptin hydrochloride supplier, dipeptidyl, peptidase, IV, DPP-IV, high, affinity, selective, inhibitors, inhibits, type, 2, diabetes, obesity, BMS477118, DPP4, BMS, 477118, Dipeptidyl, Peptidase, (DPP-IV), 6507, Tocris Bioscience
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Saxagliptin hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Saxagliptin impairs cardiac contractility.
By
Christopher Trummer on 10/15/2018
分析类型： Ex Vivo
种属： Other
细胞系/组织： heart
Guinea pig hearts were isolated and mounted on a Langendorff's setup followed by perfusion with Krebs-Henseleit solution alone or containing saxagliptin (2 µM) for 30 min. The protocol of Langendorff perfusion of isolated guinea pig hearts is displayed in the upper panel. Saxagliptin significantly impaired left ventricular developed pressure compared to controls.
