SB 415286

Cat. No. 1617 27 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective GSK-3 inhibitor

化学名： 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione

纯度： ≥99% (HPLC)

引用文献 (27)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 415286

SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

技术数据 for SB 415286

分子量	359.73
公式	C₁₆H₁₀ClN₃O₅
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	264218-23-7
PubChem ID	4210951
InChI Key	PQCXVIPXISBFPN-UHFFFAOYSA-N
Smiles	OC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C2=C(C=CC=C2)[N+]([O-])=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 415286

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	8.99	25
	DMSO	17.99	50

制备储备液 for SB 415286

以下数据基于产品分子量 359.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.56 mL	27.8 mL	55.6 mL
2.5 mM	1.11 mL	5.56 mL	11.12 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

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产品说明书 for SB 415286

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 415286

参考文献是支持产品生物活性的出版物。

Coghlan et al (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 7 793 PMID: 11033082

Cross et al (2001) Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 77 94 PMID: 11279265

Liang and Chuang (2006) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 282 3904 PMID: 17148450

If you know of a relevant reference for SB 415286, please let us know.

按标靶查看相关产品

关键词: SB 415286, SB 415286 supplier, Potent, selective, GSK-3, inhibitors, inhibits, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, SB415286, GlaxoSmithKline, GSK, Kinase, 1617, Tocris Bioscience

27 篇 SB 415286 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 415286 的部分引用包括：

Vossel et al (2015) Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. Biochem J 209 419 PMID: 25963821

Stretton et al (2015) GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling. J Biol Chem 470 207 PMID: 26348909

Sharma et al (2012) Sidestream smoke exposure increases the susceptibility of airway epithelia to adenoviral infection. PLoS One 7 e49930 PMID: 23166798

Thotala et al (2012) Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell Death Differ 19 387 PMID: 21738215

Tsai et al (2010) The mood stabilizers valproic acid and Li enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology 35 2225 PMID: 20613717

Nyati et al (2010) Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases. Anal Biochem 405 246 PMID: 20561505

Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699

Severson et al (2010) Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression. Neuro Oncol 397 592 PMID: 20617560

Yang et al (2011) Glycogen synthase kinase 3β inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons. Nature 13 459 PMID: 21398658

Napolitano et al (2018) mTOR-dependent phosphorylation controls TFEB nuclear export. Nat Commun 9 3312 PMID: 30120233

Westhoff et al (2014) Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma. PLoS One 8 e83128 PMID: 24391739

Lee et al (2014) Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice. Radiat Res 181 445 PMID: 24720754

Cuesto et al (2015) GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons. PLoS One 10 e0118475 PMID: 25764078

Noh et al (2015) Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression. BMB Rep 48 283 PMID: 25248565

Wang et al (2015) Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep 5 8566 PMID: 25858503

Dickey et al (2011) GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. J Neurooncol 104 145 PMID: 21161565

Acevedo et al (2014) Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. Hum Mol Genet 289 11007 PMID: 24610780

Ray et al (2013) Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages. PLoS One 8 e57290 PMID: 23468959

Watanabe et al (2009) Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci 122 2969 PMID: 19638411

Chen et al (2013) Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation. J Immunol 191 1744 PMID: 23851680

Thotala et al (2010) A new class of molecular targeted radioprotectors: GSK-3beta inhibitors. Int J Radiat Oncol Biol Phys 76 557 PMID: 20117291

Witte et al (2008) Microtubule stabilization specifies initial neuronal polarization. J Cell Biol 180 619 PMID: 18268107

Gross et al (2004) Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 94 960 PMID: 14976126

Gärtner et al (2006) Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation. J Cell Sci 119 3927 PMID: 16954147

Ishola et al (2007) Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells. Biochem Biophys Res Commun 1770 927 PMID: 17379415

Streets et al (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Biochim Biophys Acta 15 1465 PMID: 16551655

Garvalov et al (2007) Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci 27 13117 PMID: 18045906

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