SB 590885

Cat. No. 2650 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent B-Raf inhibitor

化学名： 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime

纯度： ≥98% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 590885

SB 590885 is a potent B-Raf inhibitor (K_d = 0.3 nM). Selective for B-Raf against 46 other kinases (K_{i app} values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-Raf^V600E. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for SB 590885

分子量	453.54
公式	C₂₇H₂₇N₅O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	405554-55-4
PubChem ID	11316960
InChI Key	DPCXEUSDRQOOGZ-QLYXXIJNSA-N
Smiles	CN(C)CCOC(C=C4)=CC=C4C1=NC(C3=CC=C(C(CC5)=NO)C5=C3)=C(C2=CC=NC=C2)N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 590885

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	4.54	10

制备储备液 for SB 590885

以下数据基于产品分子量 453.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	22.05 mL	110.24 mL	220.49 mL
0.5 mM	4.41 mL	22.05 mL	44.1 mL
1 mM	2.2 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.2 mL	4.41 mL

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产品说明书 for SB 590885

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 590885

参考文献是支持产品生物活性的出版物。

King et al (2006) Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 66 11100 PMID: 17145850

Takle et al (2006) The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett. 16 378 PMID: 16260133

Guan et al (2022) Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605 325 PMID: 35418683

If you know of a relevant reference for SB 590885, please let us know.

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关键词: SB 590885, SB 590885 supplier, glaxosmithkline, SB590885, b-raf, braf, c-raf, kinases, inhibitors, inhibits, selective, induced, pluripotent, stem, cells, iPSC, reprogramming, Raf, Kinase, Stem, Cell, Reprogramming, 2650, Tocris Bioscience

3 篇 SB 590885 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 590885 的部分引用包括：

Balaburski et al (2013) A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res 11 219 PMID: 23303345

Najm et al (2015) Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. PLoS One 522 216 PMID: 25896324

Wagenaar et al (2014) Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. Pigment Cell Melanoma Res 27 124 PMID: 24112705

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