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SCR7 pyrazine

Cat. No. 5342 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Enhances HDR efficiency
化学名： 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SCR7 pyrazine

SCR7 pyrazine enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).

We have discovered that the commercially available SCR7 material supplied by other vendors does not match the chemical structure that it is being sold under. Through detailed chemical analysis carried out by our Analytical Quality Control experts, we believe that the commercially available SCR7 material, including that used in recent publications to enhance CRISPR efficiency, is in fact an analog of SCR7 that we have named 'SCR7 pyrazine'.

View more information regarding the structure of SCR7.

技术数据 for SCR7 pyrazine

分子量 332.38
公式 C18H12N4OS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 14892-97-8
PubChem ID 10688007
InChI Key GSRTWXVBHGOUBU-UHFFFAOYSA-N
Smiles O=C(C(N=C(C3=CC=CC=C3)C(C4=CC=CC=C4)=N2)=C2N1)NC1=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SCR7 pyrazine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.44 100
ethanol 6.69 20

制备储备液 for SCR7 pyrazine

以下数据基于产品分子量 332.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for SCR7 pyrazine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SCR7 pyrazine

参考文献是支持产品生物活性的出版物。

Chu et al (2015) Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat.Biotechnol. 33 543 PMID: 25803306

Maruyama et al (2015) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat.Biotechnol. 33 538 PMID: 25798939

Greco et al (2016) Synthesis and structure determination of SCR7, a DNA ligase inhibitor Teterahedron Lett. 57 3204

Greco et al (2016) SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. DNA Repair (Amst) 43 18 PMID: 27235626

If you know of a relevant reference for SCR7 pyrazine, please let us know.

按标靶查看相关产品

关键词: SCR7 pyrazine, SCR7 pyrazine supplier, CRISPR, Cas9, HDR, NHEJ, homology, directed, repair, nonhomologous, end, joining, hematopoietic, haematopoietic, stem, cells, HSC, Reagents, Hematopoietic, Stem, Cells, 5342, Tocris Bioscience

2 篇 SCR7 pyrazine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SCR7 pyrazine 的部分引用包括：

Lei et al (2021) Dynamics and competition of CRISPR-Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing. Nucleic Acids Res 49 969-985 PMID: 33398341

John W et al (2020) RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals. Cell Host Microbe 28 712-723.e9 PMID: 33113352

您是否知道使用了 Tocris SCR7 pyrazine 的优秀论文？ 请告知我们.

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该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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