Sitagliptin phosphate

Cat. No. 6816 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective DPP IV inhibitor

化学名： (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sitagliptin phosphate

Sitagliptin phosphate is a potent and selective DPP IV (DPP4) inhibitor (IC₅₀ = 18 nM). Displays >2600-fold selectivity for DPP IV over other proline specific peptidases. Reduces blood glucose and increases GLP-1 levels after oral glucose tolerance test in normal and diet-induced obese mice.

化合物库 for Sitagliptin phosphate

Sitagliptin phosphate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Sitagliptin phosphate

分子量	505.31
公式	C₁₆H₁₅F₆N₅O.H₃O₄P
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	654671-78-0
PubChem ID	6451150
InChI Key	IQFYVLUXQXSJJN-SBSPUUFOSA-N
Smiles	OP(O)(O)=O.N[C@H](CC1=C(C=C(C(F)=C1)F)F)CC(N2CCN3C(C2)=NN=C3C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sitagliptin phosphate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	25.27	50
	DMSO	25.27	50

制备储备液 for Sitagliptin phosphate

以下数据基于产品分子量 505.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.96 mL	19.79 mL	39.58 mL
2.5 mM	0.79 mL	3.96 mL	7.92 mL
5 mM	0.4 mL	1.98 mL	3.96 mL
25 mM	0.08 mL	0.4 mL	0.79 mL

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产品说明书 for Sitagliptin phosphate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sitagliptin phosphate

参考文献是支持产品生物活性的出版物。

Kim et al (2005) (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem. 48 141 PMID: 15634008

If you know of a relevant reference for Sitagliptin phosphate, please let us know.

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关键词: Sitagliptin phosphate, Sitagliptin phosphate supplier, DPPIV, DPP4, inhibitors, inhibits, potent, selective, CD26, Dipeptidyl, Peptidase, IV, (DPP-IV), 6816, Tocris Bioscience

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