SL 0101-1

Cat. No. 2250 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective ribosomal S6 kinase (RSK) inhibitor

化学名： 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one

纯度： ≥95% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SL 0101-1

SL 0101-1 is a selective inhibitor of ribosomal S6 kinase (RSK) (IC₅₀ = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

技术数据 for SL 0101-1

分子量	516.46
公式	C₂₅H₂₄O₁₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	77307-50-7
PubChem ID	14825856
InChI Key	SXOZSDJHGMAEGZ-UHFFFAOYSA-N
Smiles	O=C1C3=C(C=C(O)C=C3O)OC(C4=CC=C(O)C=C4)=C1OC2C(O)C(OC(C)=O)C(OC(C)=O)C(C)O2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SL 0101-1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	5.16	10

制备储备液 for SL 0101-1

以下数据基于产品分子量 516.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	19.36 mL	96.81 mL	193.63 mL
0.5 mM	3.87 mL	19.36 mL	38.73 mL
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL

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产品说明书 for SL 0101-1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SL 0101-1

参考文献是支持产品生物活性的出版物。

Smith et al (2005) Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 65 1027 PMID: 15705904

Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID: 17850214

Godeny and Sayeski (2006) ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am.J.Cell.Physiol. 291 1308

Saha et al (2012) RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem.J. 447 159 PMID: 22827337

If you know of a relevant reference for SL 0101-1, please let us know.