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Spautin 1

Cat. No. 5197 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： USP10 and USP13 inhibitor; inhibits autophagy
化学名： 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Spautin 1

Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

化合物库 for Spautin 1

Spautin 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Spautin 1

分子量 271.26
公式 C15H11F2N3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1262888-28-7
PubChem ID 51037431
InChI Key AWIVHRPYFSSVOG-UHFFFAOYSA-N
Smiles FC1=CC=C(N=CN=C2NCC3=CC=C(F)C=C3)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Spautin 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.13 100

制备储备液 for Spautin 1

以下数据基于产品分子量 271.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.87 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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参考文献 for Spautin 1

参考文献是支持产品生物活性的出版物。

Salabei et al (2013) PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 451 375 PMID: 23421427

Liu et al (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 223 PMID: 21962518

If you know of a relevant reference for Spautin 1, please let us know.

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关键词: Spautin 1, Spautin 1 supplier, class, III, PI3, kinase, autophagy, inhibitors, inhibits, USP10, USP13, deubiquitinating, enzymes, vps34, Deubiquitinating, Enzymes, Autophagy, 5197, Tocris Bioscience

3 篇 Spautin 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Spautin 1 的部分引用包括：

Catarina et al (2020) Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle. J Cell Physiol 235 7370-7382 PMID: 32039481

Tinghu et al (2021) Targeting oncoproteins with a positive selection assay for protein degraders. Sci Adv 7 PMID: 33547076

Ji Eun et al (2022) USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity. Mol Med 28 164 PMID: 36585612

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