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Submit Reviewst-Ht31
说明： Inhibits PKA/AKAP interactions; cell permeable
纯度： ≥95% (HPLC)
生物活性 for st-Ht31
st-Ht31 is a stearated form of the peptide Ht-31. Inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP) in cell extracts. Cell permeable.
技术数据 for st-Ht31
| 分子量 | 2798.27 |
| 公式 | C129H217N29O39 |
| 序列 |
DLIEEAASRIVDAVIEQVKAAGAY (Modifications: Asp-1 = N-terminal Ste) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 188425-80-1 |
| PubChem ID | 16143012 |
| InChI Key | AHVAWKAVLPRRQS-MUBBMYIHSA-N |
| Smiles | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for st-Ht31
| 溶解性 | Soluble to 1 mg/ml in 0.01M PBS (pH 7.4) |
产品说明书 for st-Ht31
参考文献 for st-Ht31
参考文献是支持产品生物活性的出版物。
Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID: 28192412
Vijayaraghavan et al (1997) Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J.Biol.Chem. 272 4747 PMID: 9030527
Carr et al (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J.Biol.Chem. 267 13376 PMID: 1618839
Stival et al (2018) Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J.Biol.Chem. 293 9435 PMID: 29700114
If you know of a relevant reference for st-Ht31, please let us know.
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关键词: st-Ht31, st-Ht31 supplier, st_Ht31, st, Ht, 31, stearated, A-kinase, anchoring, protein, AKAP, cAMP-dependent, PKA, scaffolding, proteins, Protein, Kinase, A, A-kinase-anchoring, protiens, 6286, Tocris Bioscience
2 篇 st-Ht31 的引用文献
引用文献是使用了 Tocris 产品的出版物。 st-Ht31 的部分引用包括：
G Stanley et al (2022) Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep 40 111073 PMID: 35830806
Martin E et al (2020) TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6. Eneuro 7 PMID: 32887692
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