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SU 6656

Cat. No. 6475 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
化学名： 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SU 6656

SU 6656 is a potent ATP-competitive Src family kinase inhibitor (IC50 values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC50 = 0.22 μM for the α2 kinase domain). Cell permeable.

技术数据 for SU 6656

分子量 371.45
公式 C19H21N3O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 330161-87-0
PubChem ID 5312137
InChI Key LOGJQOUIVKBFGH-YBEGLDIGSA-N
Smiles CN(S(=O)(C1=CC=C2NC(/C(C2=C1)=C\C3=CC4=C(N3)CCCC4)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SU 6656

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.15 100

制备储备液 for SU 6656

以下数据基于产品分子量 371.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for SU 6656

参考文献是支持产品生物活性的出版物。

Ross et al (2017) Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sora. Cell.Chem.Biol. 24 813 PMID: 28625738

Blake et al (2000) SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol.Cell Biol. 20 9018 PMID: 11074000

If you know of a relevant reference for SU 6656, please let us know.

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关键词: SU 6656, SU 6656 supplier, SU6656, potent, Src, family, kinases, inhibitors, inhibits, Lck, Yes, Lyn, Fyn, AMPK, Kinases, 6475, Tocris Bioscience

1 篇 SU 6656 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SU 6656 的部分引用包括：

Andrii et al (2020) GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Mov Disord 35 2279-2289 PMID: 32964492

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