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Sulfasalazine

Cat. No. 4935 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
化学名： 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
纯度： ≥97% (HPLC)
说明书
引用文献 (3)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sulfasalazine

Sulfasalazine is an inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system Xc (SXC). Inhibitor of folate transporter 1 (SLC19A1); inhibits cellular uptake of Methotrexate (Cat. No. 1230) and cyclic dinucleotides, including 2',3'-cGAMP (Cat.No. 5945). Anti-inflammatory. Induces ferroptosis.

化合物库 for Sulfasalazine

Sulfasalazine is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Sulfasalazine

分子量 398.39
公式 C18H14N4O5S
储存 Store at RT
纯度 ≥97% (HPLC)
CAS Number 599-79-1
PubChem ID 5359476
InChI Key OQANPHBRHBJGNZ-BKUYFWCQSA-N
Smiles OC1=CC=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sulfasalazine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.84 100

制备储备液 for Sulfasalazine

以下数据基于产品分子量 398.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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产品说明书 for Sulfasalazine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Sulfasalazine

参考文献是支持产品生物活性的出版物。

Robe et al (2004) In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasal. in human glioblastomas. Clin.Cancer Res. 10 5595 PMID: 15328202

Lo et al (2010) Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Curr.Oncol. 17 9 PMID: 20567622

Sontheimer and Bridges (2012) Sulfasalazine for brain cancer fits. Expert Opin.Invest.Drugs 21 575 PMID: 22404218

Jansen et al (2004) Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. Arthritis Rheum. 50 2130 PMID: 15248210

Luteijn et al (2019) SLC19A1 transports immunoreactive cyclic dinucleotides. Nature 573 434 PMID: 31511694

Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443

If you know of a relevant reference for Sulfasalazine, please let us know.

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关键词: Sulfasalazine, Sulfasalazine supplier, antirheumatic, antiinflammatories, antiinflammatory, arthritis, system, XC, SXC, cysteine-glutamate, antiporters, NF-kappaB, NF-kB, NF-κB, inhibitors, inhibits, ferroptosis, inducers, induces, folate, transporter, 1, cGAMP, SLC19A1, xCT, SLC11A7, NF-kB/IkB, Ferroptosis, Other, Ion, Pumps/Transporters, 4935, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Sulfasalazine (Salicylazosulfapyridine), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 篇 Sulfasalazine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sulfasalazine 的部分引用包括：

Christopher T et al (2017) In vitro modeling of HIV proviral activity in microglia. FEBS J 284 4096-4114 PMID: 29114997

Yeligar et al (2009) Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 183 5964 PMID: 19828633

Shin et al (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis 7 86 PMID: 30425240

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Pathways for Sulfasalazine

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.