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T3 CLK

Cat. No. 7570 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B
化学名： 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for T3 CLK

T3 CLK is a potent and selective pan CDC-like kinase (CLK) inhibitor (IC50 values are 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively). T3 CLK also inhibits DYRK1A/B (IC50 values are 230 nM and 260 nM for DYRK1B and DYRK1A, respectively in cellular assays). Exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3 CLK is cell permeable, stable and non-toxic.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T3 CLK probe summary on the SGC website.

技术数据 for T3 CLK

分子量 482.58
公式 C28H30N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2109805-56-1
PubChem ID 132585205
InChI Key IEFFSHLHNYVSEF-UHFFFAOYSA-N
Smiles O=C(NC=1N=C2C=CC(=CN2C1)C=3C=CN=CC3)C4=CC=C(C=C4)C(C(=O)N5CCN(C)CC5)(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for T3 CLK

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.13 50 温和加热
ethanol 4.83 10 温和加热

制备储备液 for T3 CLK

以下数据基于产品分子量 482.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.14 mL 20.72 mL 41.44 mL
2.5 mM 0.83 mL 4.14 mL 8.29 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
25 mM 0.08 mL 0.41 mL 0.83 mL

Molarity Calculator

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参考文献 for T3 CLK

参考文献是支持产品生物活性的出版物。

Funnell et al (2017) CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor. Nat.Commun. 8 7 PMID: 28232751

If you know of a relevant reference for T3 CLK, please let us know.

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关键词: T3 CLK, T3 CLK supplier, T3CLK, inhibitors, inhibits, Cdc2-like, kinase, Clk, kinases, DYRK, DYRK1A, DYRK1B, potent, selective, permeable, colorectal, cancer, CLK, (Cdc2-like, kinases), 7570, Tocris Bioscience

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