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TC-A 2317 hydrochloride

Cat. No. 4066 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent, selective Aurora kinase A inhibitor
化学名： 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-A 2317 hydrochloride

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

技术数据 for TC-A 2317 hydrochloride

分子量 392.93
公式 C19H28N6O.HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1245907-03-2
PubChem ID 46911725
InChI Key DXVATYHPJJPMIN-UHFFFAOYSA-N
Smiles CC1=CC(NC2=NNC(C)=C2)=NC(NC(C)CCCC(C)(C)O)=C1C#N.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-A 2317 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.29 100
ethanol 19.65 50

制备储备液 for TC-A 2317 hydrochloride

以下数据基于产品分子量 392.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.72 mL 25.45 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for TC-A 2317 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for TC-A 2317 hydrochloride

参考文献是支持产品生物活性的出版物。

Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709 PMID: 20573509

If you know of a relevant reference for TC-A 2317 hydrochloride, please let us know.

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关键词: TC-A 2317 hydrochloride, TC-A 2317 hydrochloride supplier, inhibits, aurora, kinase, a, inhibitors, antitumor, Aurora, A, Kinases, 4066, Tocris Bioscience

3 篇 TC-A 2317 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-A 2317 hydrochloride 的部分引用包括：

Min et al (2016) The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget 7 84718 PMID: 27713168

Wang et al (2019) EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions. Cell Stem Cell 24 419 PMID: 30713094

Lucas et al (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559 211-216 PMID: 29973724

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