TC-G 24

Cat. No. 4353 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective GSK-3β inhibitor

化学名： N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC-G 24

TC-G 24 is a potent GSK-3β inhibitor (IC₅₀ = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

技术数据 for TC-G 24

分子量	330.73
公式	C₁₅H₁₁ClN₄O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1257256-44-2
PubChem ID	49857866
InChI Key	JYCNWQGNEJYDQS-UHFFFAOYSA-N
Smiles	CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-G 24

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.31	10 温和加热

制备储备液 for TC-G 24

以下数据基于产品分子量 330.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	30.24 mL	151.18 mL	302.36 mL
0.5 mM	6.05 mL	30.24 mL	60.47 mL
1 mM	3.02 mL	15.12 mL	30.24 mL
5 mM	0.6 mL	3.02 mL	6.05 mL

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产品说明书 for TC-G 24

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC-G 24

参考文献是支持产品生物活性的出版物。

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766

If you know of a relevant reference for TC-G 24, please let us know.

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关键词: TC-G 24, TC-G 24 supplier, TC-G24, glycogen, synthase, kinase, 3, beta, b, β, gsk3beta, gsk3β, potent, inhibits, inhibitors, selective, brain, penetrant, liver, hinge, region, binder, Glycogen, Synthase, Kinase, 4353, Tocris Bioscience

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