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TC KHNS 11

Cat. No. 6079 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6079 has been discontinued.

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说明： Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
化学名： 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for TC KHNS 11

TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.

技术数据 for TC KHNS 11

分子量 492.53
公式 C28H24N6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1431540-99-6
PubChem ID 86732669
InChI Key QYTXJLQBSYAMGR-UHFFFAOYSA-N
Smiles O=C(N1CCN(C(C)=O)CC1)C2=CC=CC(C3=NC=NC(C=C4)=C3C=C4C(C=C5C#N)=CN=C5OC)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC KHNS 11

参考文献是支持产品生物活性的出版物。

Hoegenauer et al (2016) Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 7 762 PMID: 27563400

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关键词: TC KHNS 11, TC KHNS 11 supplier, TCKHNS11, PI, 3-kinase, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, pi3kβ, inhibitors, inhibits, 3-Kinase, 6079, Tocris Bioscience

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