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TC Mps1 12

Cat. No. 4750 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective Mps1 kinase inhibitor
化学名： 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for TC Mps1 12

TC Mps1 12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.

技术数据 for TC Mps1 12

分子量 324.38
公式 C17H20N6O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1206170-62-8
PubChem ID 70682875
InChI Key XDEFNAWAKYQBQY-UHFFFAOYSA-N
Smiles NC1=C(C#N)C(NC(C)(C)C)=NC(NC2=CC=C(C(N)=O)C=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC Mps1 12

参考文献是支持产品生物活性的出版物。

Kusakabe et al (2012) Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med.Chem.Lett. 3 560 PMID: 24900510

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关键词: TC Mps1 12, TC Mps1 12 supplier, TCMps112, TC, Mps1, 12, potent, selective, monopolar, spindle, 1, mps1, antitumor, orally, active, Checkpoint, Control, Kinases, Monopolar, Spindle, Kinase, 4750, Tocris Bioscience

1 篇 TC Mps1 12 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC Mps1 12 的部分引用包括：

Choi et al (2017) TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br.J.Pharmacol. 174 1810 PMID: 28299790

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